Elsada A, Zalin-Miller A, Knott CS, Caravotas L. A registry study of relapsed or refractory multiple myeloma pre-exposed to 3 or more therapies including a proteasome inhibitor, an immunomodulatory agent and cd38-targeted monoclonal antibody therapy in England. eJHaem 2021:1-5. https://pubmed.ncbi.nlm.nih.gov/35844690/
Some patients with multiple myeloma are receiving treatment in clinical practice in England after prior exposure to a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. We investigated the characteristics of these patients, their outcomes, and the salvage therapies they received using the national cancer registry for England and linked healthcare data. After a median follow-up time of 6.4 months from T 0, median overall survival and time to next treatment were 8.2 and 5.3 months, respectively. This real-world data provide useful clinical insight into a little-studied patient population and highlight the poor outcomes in the UK setting.